Pioxy LA®

Product Group	:	Antibacterials
Pharmaceutical Form	:	Solution for Injection
Active Ingredient	:	Oxytetracycline Dihydrate
Target Type	:	Cattle, Sheep, Goat
Package Form	:	50 - 100 - 250 ml

For Animal Use Only

Composition - Pharmacological Properties
Indications – Usage
Undesirable Effects – Warnings

For Animal Use Only

PİOXY LA

Solution for Injection

Veterinary Systemic Antibacterial

COMPOSITION

Pioxy LA Solution for Injection is a yellow-amber colored, clear sterile solution containing Oxytetracycline dihydrate equivalent to 200 mg of Oxytetracycline base in each ml.

PHARMACOLOGICAL PROPERTIES

Pioxy LA Solution for Injection is an antibacterial containing oxytetracycline, it provides long-lasting blood density in a single dose. Oxytetracycline is a member of the tetracyclines, a broad-spectrum bacteriostatic antibiotic group that inhibits protein synthesis in bacteria. After oxytetracycline enters the cell by active transport and some passive diffusion, it binds reversibly to the receptors on the 30S subunit of the bacterial ribosome and prevents the binding of aminoacyl-transfer RNA to the ribosome complex. This effectively prevents amino acids from participating in peptide chain elongation and inhibits protein synthesis. It also inhibits the activity of bacterial enzymes by forming chelates with metals in their structure.

The effect of oxytetracycline on bacteria is as follows:

It has a good effect on Gram-positive aerobes (Bacillus sp., Corynebacterium sp., Erysipelothrix rhusiopathia, Listeria monocytogenes and Streptococcus sp.),

Gram-negative bacteria (Actinobacillus sp., Bordetella sp., Francisella tularensis, Haemophilus sp., Pasteurella haemophilus sp., Pasteurella haemophilus sp., P. Yersinia sp., Campylobacter fetus, Borrelia sp., Leptospira sp. and Moraxella bovis), Anaerobes (Actinomyces sp., Fusobacterium sp.,) and Mycoplasma sp., Chlamydia sp., Ehrlichia sp., Coxiella burnetti, Theileria, Eperythrozoon and Anaplasmas.

Due to acquired resistance, its effect on Staphylococcus sp., Enterococcus sp., Enterobacter sp., E. coli, Klebsiella sp., Proteus sp., Salmonella sp., Anaerobic bacteria, Bacteroides sp. and Clostridium sp is variable.

Mycobacterium sp., Proteus vulgaris, Pseudomonas aeroginosa, Serratia sp., Mycoplasma bovis, and M. hyopneumoniae are considered resistant to tetracyclines.

When administered intramuscularly in a single recommended dose, it is rapidly and highly absorbed from the application site and distributed to tissues. The level of oxytetracycline in the blood peaks at the end of the 4th hour and remains at this level until approximately 8 hours after administration. The concentration then decreases slowly but maintains therapeutic concentrations for 84-96 hours. Circulating oxytetracycline is 20-40% bound to plasma proteins and is well distributed to all body parts. The remainder of the drug forms a depot at the injection site, where the drug is slowly absorbed and distributed throughout the body, providing an effect that lasts for 3-4 days. Oxytetracycline is excreted from the body primarily by glomerular filtration through the kidneys and secondarily with bile.

AREA OF USE / INDICATIONS

Pioxy LA Solution for Injection is used in the treatment of the following diseases caused by microorganisms sensitive to oxytetracycline in cattle, sheep and goats:

Respiratory system, digestive system, urogenital system and foot infections, infectious keratoconjunctivitis, septic wounds, pre- and post-operative wounds, secondary bacterial infections after viral infections, anaplasmosis.

USAGE AND DOSAGE

Unless recommended otherwise by the veterinarian, it should only be administered as a single dose by deep intramuscular (IM) route.

Pharmacological dose: 20 mg/kg body weight.

Practical Dose: 1 ml per 10 kg body weight. If necessary, the dose is repeated after 3 days. When more than 20 ml for cattle and 5 ml for sheep and goats are required, the total amount should be divided and injected into two separate places. It should never be used intravenously. Attention should be paid to asepsis and antisepsis when using. Oxytetracycline does not completely eliminate Chlamidia infection in the herd.

UNDESIRED EFFECTS

When used in the last stages of pregnancy and during the tooth development period, it can cause developmental disorders in the fetus and color changes in the teeth. Since it causes tissue damage and leaves residue in the application area in animals fed for meat in parenteral administration, the same injection should not be done repeatedly in the same area. A slight swelling may occur at the injection site, which will resolve spontaneously within a few days. Although rare, anaphylactic shock may occur, which is characterized by increased salivation, rapid breathing, grinding of the teeth, tremor in the muscles, swelling of the eyelids and collapse. In such a case, the drug is discontinued and the adrenaline solution is administered. When used in high doses and for a long time, it can cause fatty hepatic degeneration in pre-existing hepatic insufficiency and pregnant animals. Tetracyclines can cause photosensitization, an allergic reaction and a temporary local reaction at the injection sites. After injection, darkening of urine color due to transient hemoglobinuria may occur in cattle.

DRUG INTERACTIONS

Tetracyclines lose their effectiveness when diluted with infusion fluids. It should not be used together wibeta-lactamtam and aminoglycoside antibiotics. Tetracyclines increase the renal effect of methoxyflurane and may suppress the activity of prothrombin. It should not be used with Penicillin G sodium, penicillin G potassium, sodium bicarbonate, thiopental sodium, warfarin sodium, cephalatin sodium, cefapirin sodium, amikacin sulfate, aminophylline, amphotericin B, dimenhydrinate, iron dextran, erythromycin glucefate, heparin sodium, phenobarbital sodium, hydrocortisone, sodium succinate chloride, calcium gluconate, chloramphenicol sodium succinate, methicillin sodium, morphine sulfate due to pharmacological incompatibility.

RESIDUAL WARNINGS FOR FOOD PRODUCING ANIMALS

Drug Residue Elimination Period: During the treatment and after the drug administration, cattle, sheep and goats should not be sent to slaughter until 28 days after. Milk obtained from lactating cattle, sheep and goats during the treatment and for 12 days (24 milkings) after the last drug administration should not be offered for human consumption. Due to the long removal time of drug residues in milk, it is not recommended to be applied to cows, sheep and goats producing milk for human consumption.

CONTRAINDICATIONS

It is not administered intravenously. It should not be used in animals sensitive to tetracycline and those with hepatic and renal failure.

Use in pregnancy:Tetracyclines should not be used in the first and last 1/3 of pregnancy due to their undesirable effects. However, in abortions caused by Chlamydia sp in sheep, it can be used by the physician and the animal owner by calculating the benefit and harm.

GENERAL PRECAUTION

Consult your veterinarian before use and in case of an unexpected effect. Keep out of reach of children. Do not buy or use products with damaged packaging.

PRECAUTIONS TO BE TAKEN AND RECOMMENDATIONS FOR PHYSICIANS

Avoid direct contact with the product. In case of contact with eyes and skin, the contact area should be washed with plenty of water. There is no specific antidote. Hands should be washed thoroughly after use. It should not be used concurrently with vaccines.

END DISPOSAL AND WARNINGS FOR NON-TARGET SPECIES

It should not be used on horses, cats and dogs.

STORAGE CONDITIONS AND SHELF LIFE

Shelf life is 2 years from the date of manufacture. Store in the box at room temperature (15-25°C), away from sunlight. Darkening may occur in the color of the product in contact with the air, but this does not change the effectiveness of the product.