Penidro LA®

Product Group	:	Antibacterials
Pharmaceutical Form	:	Suspension for Injection
Active Ingredient	:	Dihydrostreptomycin Sulphate, Procaine Benzylpenicillin, Benzathine Benzylpenicillin
Target Type	:	Cattle, Horse, Sheep, Dog
Package Form	:	100 ml

For Animal Use Only

Composition - Pharmacological Properties
Indications – Usage
Undesirable Effects – Warnings

For Animal Use Only

PENİDRO LA

Suspension for Injection

Veterinary Systemic Antibacterial

COMPOSITION

Penidro LA Suspension for Injection is a ready-to-use, long-acting, sterile, aqueous suspension for injection containing 100,000 IU Procaine Penicillin G, 100,000 IU Benzathine Penicillin G and 250 mg Dihydrostreptomycin sulfate equivalent to 200 mg Dihydrostreptomycin base in ml.

PHARMACOLOGICAL PROPERTIES

Penidro LA Suspension for Injection is a broad-spectrum, long-acting formulation effective against gram-positive and gram-negative bacteria sensitive to the combination of penicillin and dihydrostreptomycin. Benzathine and procaine penicillin G in combination cause their death by disrupting the cell wall synthesis of susceptible bacteria, especially during the growth period. This also allows streptomycin to enter the bacteria at higher concentrations. Thus, dihydrostreptomycin, which passes into bacteria at higher concentrations, acts by disrupting protein synthesis. This joint and mutually reinforcing synergistic effect is bacteriostatic and bactericidal even at very small doses. Since penicillin is effective against gram-positive and dihydrostreptomycin gram-negative bacteria, its spectrum has been expanded with a synergistic effect.

The synergistic effect resulting from the combination of penicillin-dihydrostreptomycin has a spectrum that includes both gram-positive and gram-negative bacteria. It has been shown to be effective against the following bacteria in vitro: Corynebacterium pyogenes, Klebsiella pneumonia, Listeria sp., Pasteurella haemolytica, P. multocida, Staphylococcus sp., Streptococcus sp., Peptostreptecoccus sp., Erysipelothrix insidiosa, Esstridium colichia sp., ., Moraxella sp., Actinobacillus lignieresi, Haemophilus sp., and Salmonella sp.

Due to its depot effect, it is gradually absorbed from the injection site and is partially free and partially protein-bound (80-90% of penicillin, 3% of dihydrostreptomycin) in the blood. It passes into kidney, liver, lung, skin and soft tissue, mucosa, serosa and connective tissue. It is excreted in large amounts by the kidneys and in smaller amounts by bile, milk and sweat without undergoing a metabolic change of 80-90%.

AREA OF USE / INDICATIONS

Penidro LA Suspension for Injection is used in the treatment of digestive system, respiratory system, urogenital system infections, and secondary bacterial infections caused by penicillin and dihydrostreptomycin sensitive bacteria in cattle, sheep, horses, and dogs.

USAGE AND DOSAGE

Unless advised otherwise by the veterinarian,

Pharmacological dose:

For all target animals;

Penicillin: 10.000 IU/kg bw,

Dihydrostreptomycin: 10 mg/kg bw,

Practical dose:

20 kg body weight/1 ml for all target species intramuscularly (i.m.)

Animal Type	Body weight (kg)	Dose (ml)
Cattle - Horse	400 kg	20 ml
Calf - Heifer	200 kg	10 ml
Calf - Foal	100 kg	5 ml
Sheep	40 kg	2 ml
Dog	10 kg	0,5 ml

Generally, a single dose is sufficient in the treatment, and in severe cases, the application can be repeated at an interval of 48 hours if necessary.

The suspension should be homogenized by vigorously shaking the bottle before use.

It is not applied intravenously.

Repeated injections into the same area, especially in horses, should be avoided.

When using, asepsis and antisepsis should be followed.

UNDESIRED EFFECTS

Allergic and anaphylactic side effects such as urticaria, skin lesions, nausea, vomiting, respiratory distress, pulmonary and laryngeal edema, vasomotor central paralysis and coma, and death may occur in sensitive animals. Especially in animals with impaired renal function, high plasma concentrations of dose-dependent streptomycin may have neurotoxic, nephrotoxic, and ototoxic effects. The dose should be reduced to an adequate level in renal failure.

DRUG INTERACTIONS

It shows physical and chemical incompatibility with calcium, sodium, potassium, and dextrose solutions, acid and alkalis, chlorothiazide, phenobarbitone, phenytoin sodium, Vitamin C and B group vitamins, and antagonist interactions with tetracyclines, ampicillin, cloxacillin, methicillin, carbenicillin, sulfadiazine, and nitrofurantoin. Due to the possible toxic effects of dihydrostreptomycin, it should not be used together with other drugs (other aminoglycosides, furosemide, sulfonamides, tetracyclines, anesthetics, cephalosporins etc.) In addition, it should be kept in mind that the use of penicillin-streptomycin combinations, especially in high doses, in animals treated with general anesthesia and/or muscle relaxants may increase the neuromuscular blocking effect and may cause death.

SYMPTOMS OF OVERDOSE, PRECAUTIONS, AND ANTIDOTE

When the deafness that occurs when used in more than the recommended doses and times becomes permanent, it cannot be treated. In case of sensitization-related side effects, drug administration should be stopped immediately and treatment with cardiac and respiratory analeptics, antihistamines, corticosteroids, and adrenaline should be started according to the clinical picture.

RESIDUAL WARNINGS FOR FOOD PRODUCING ANIMALS

Drug Residue Elimination Period: During the treatment and after the last drug application, cattle and sheep raised for meat should not be sent to slaughter until 60 days have passed. Cow and sheep milk obtained during the treatment and for 15 days (30 milkings) after the last drug administration should not be offered for consumption. It is not recommended to be applied to sheep and cows from which milk is obtained for human consumption, due to the long removal time of drug residues in milk.

CONTRAINDICATIONS

It should not be used in animals hypersensitive to penicillin, dihydrostreptomycin, and cephalosporin and in animals with kidney failure. It should not be administered intravenously.

Use in pregnancy: Dihydrostreptomycin should not be used in pregnant animals due to its neurotoxic, nephrotoxic, and ototoxic effects on the fetus.

GENERAL PRECAUTIONS

Consult your veterinarian before use and in case of an unexpected effect. Keep out of reach of children.

PRECAUTIONS TO BE TAKEN AND RECOMMENDATIONS FOR PHYSICIANS

Penicillin sensitivity: Sensitivity may be caused by penicillin injection, ingestion, inhalation, or tissue contact. Those who are sensitive to penicillin should use gloves during application. If you experience swelling of the face, eyes, or lips, or difficulty in breathing as a result of the injection, swallowing, inhalation or contact with penicillin, seek medical attention immediately.

STORAGE CONDITIONS AND SHELF LIFE

It should be stored at temperatures between 15°C-25°C, protected from light. Shelf life is 2 years from the date of manufacture. Opened bottles should be consumed within 28 days at +4°C.

END DISPOSAL AND WARNINGS FOR NON-TARGET SPECIES

As with other penicillins, it should not be used on small herbivorous animals such as hamsters, rabbits, and guinea pigs, and on animals such as geese and ducks. Due to sensitivities to streptomycin, this preparation should not be used in cats.

TRADE DRESS

Penidro LA Suspension for Injection; It is presented in 20, 50, 100 ml transparent colored glass bottles and 100, 250 ml plastic bottles with cardboard boxes, and 500 ml plastic bottles without cardboard boxes.