Product Group | : | Parasiticides |
Pharmaceutical Form | : | Pour-On Solution |
Active Ingredient | : | Cypermethrin |
Target Type | : | Cattle, Sheep, Goat |
Package Form | : | 500 ml |
For Animal Use Only
For Animal Use Only
Pour-On Solution
Veterinary Ectoparasitic (Insecticide-Acaricide)
Cypercel Pour-On Solution is a blue-colored, slightly aromatic odorous solution containing 25 mg of Cypermethrin (cis: trans 50:50) per ml.
Cypermethrin, which is the active ingredient of Cypercel Pour-On Solution, is a synthetic insecticide from the pyrethroid Type II group. Synthetic pyrethroids act as contact and stomach poisons similar to natural pyrethroids, causing rapid death in parasites after overstimulation and movement incompatibility. They do not produce a systemic effect. Pyrethroid group insecticides are lipophilic. Thus, they easily pass through the cuticle rich in lipoid molecules of parasitic insects and reach their point of action. Ectoparasites ingest cypermethrin by oral route and contact. Cypermethrin creates its neurotoxic effect in the parasite cell by allowing sodium channels in the nerve cell membrane to either remain open for a long time or close slowly, allowing excessive sodium to enter the nerve cell. This causes repeated discharge and sudden depolarization of the nerve cell membrane of the parasite, which results in restlessness with convulsions, and then incoordination and paralysis in the parasite. Cypermethrin is particularly effective in sensory nerves, neuronal secretion cells, and nerve endings. As a result of sufficient Cypermethrin activity, death occurs. When cypermethrin is applied to the skin, it penetrates the skin and disperses. Since it is a lipophilic substance, it accumulates mostly in adipose tissue, liver, and kidney in the body. Cypermethrin applied through the skin is absorbed at very low levels, and only 2% of the drug administered in a single dose is excreted in the urine and 0.5% in the stool between 2-6 days.
Toxicity: The acute toxicity of Cypermethrin, which is among the substances with toxicity class II according to the classification of the World Health Organization (WHO), is variable and depends on factors such as the cis: trans ratio of the drug, the species, age, breed of the animal and the solvent in the formulation. The cis isomer is more toxic than the trans isomer. The acute oral LD50 value of cis: trans 90:10 cypermethrin is 367 mg/kg body weight in female rats, the same value for cis: trans 40:60 is 891 mg/kg body weight. Acute LD50 value in rats was determined between 400-4000 mg/kg body weight.
Cypercel Pour-On Solution is used to treat and control single and multi-host tick infestations, scabies agents, lice infestations, biting and irritating fly infestations, and larval myiasis infestations in cattle, sheep, and goats.
Unless recommended otherwise by the veterinarian, Cypercel Pour-On Solution is applied by pouring or spraying on the dorsal line from the top of the animal's head to the tail and/or on the settlement areas of the parasites, thanks to the specially prepared packaging form. The pharmacological dose of Cypermethrin administered to domestic ruminants in the form of pouring on the back is kept between 2-2.5 mg/kg body weight.
Practical Dose Chart:
In cattle
Body Weight | Cypercel PO |
---|---|
Up to 100 kg body weight | 10 ml |
Between 100-200 kg body weight | 20 ml |
Over 300 kg body weight | 30 ml |
In sheep and goats
Since sheep and goats have longer wool, a dose of 5 mg Cypermethrin/kg body weight is taken into account, taking into account the inevitable loss of the medicine.
Body weight | Cypercel PO |
---|---|
5 kg body weight | 1 ml |
25 kg body weight | 5 ml |
50 kg body weight | 10 ml |
It is sufficient to apply the amount of drug to be used for fly and lice control in all animal species along the ridgeline.When tick control is aimed, the drug should also be applied to places where ticks can be found, such as armpits, groin area, around nails, nipples, and ear bottoms. When the treatment of scabies cases in cattle, sheep, and goats is targeted, the recommended one-time drug doses are doubled according to the species. The drug applied once, protects animals against reinfestations for 2-6 weeks, depending on the host, parasite, and seasonal conditions. Cypercel PO is a ready-to-use drug and does not need to be diluted.
This product is only applied to the back and parasitic areas against external parasite infestations in cattle, sheep, and goats. Recommended treatment doses should not be exceeded. Otherwise, it may cause poisoning. Spraying should be avoided in extremely hot weather. It should not be applied to the eyes and mouth circles of animals and heavily lesioned skin areas. Depending on external factors such as environmental temperature, and low or high parasite load on the animal's body, the duration of the protective effect may change more or less. It should not be used for animals under 4 weeks old unless necessary.
When applied at the recommended treatment doses according to the target species, it does not cause any undesirable side effects. Rarely, some animals may experience mild restlessness within 2 days of drug administration. These effects are short-term and temporary.
When cypermethrin and other pyrethroids are used together or in combination with organophosphorus insecticides in vivo, their inhibitory activities and neurotoxic effects on the liver microsomal enzyme system increase. Immune system inhibitory effects become more pronounced.
Cypercel Pour-On Solution can cause acute poisoning in target pets when used in very high doses and repeated for a long time. In acutely poisoned animals, digestive system disorders such as vomiting and diarrhea, chronic convulsions, motor incompatibility, and similar neuromuscular disorders, and clinical symptoms that can go up to dyspnea, cyanosis, and death are encountered. There is no outstanding antidote for poisoning with synthetic pyrethroids. Symptomatic treatment is applied according to the clinical signs of poisoning. In this context, the stomach is washed to ensure that the drug is quickly eliminated from the body. Retaining and binding agents are applied on the surface. The patient is given emetics. Muscle relaxants are used in case of excessive neuromuscular symptoms. Stimulants are also preferred in case of central depression.
Drug Residue Elimination Period: During the treatment and after the last drug application, cattle, sheep, and goats raised for meat should not be sent to slaughter until 14 days after. During the treatment and after the last drug application, milk obtained before 15 days (30 milkings) in dairy cows and 10 days (20 milkings) in sheep and goats should not be offered for human consumption. It is not recommended to be applied to cows, sheep, and goats from which milk is obtained for human consumption, due to the long removal time of drug residues in milk.
Cypercel Pour-On Solution, is for external use only in cattle, sheep, and goats. It should not be used in animals sensitive to the active substance.
Consult your veterinarian before use and in case of an unexpected effect. Keep out of reach of children. Store away from foodstuffs and with the lid tightly closed. Do not buy or use products with damaged packaging. It is poisonous.
Practitioners should wear protective work clothes and use rubber gloves. It is envisaged to apply the drug in well-ventilated environments or outdoors. Practitioners should be careful not to get the medicine on their skin and eyes. In case of contamination, it should be washed again with clean water as soon as possible. Nothing should be eaten or drunk during the application phase. It is recommended to wash hands and face after application. If taken by mouth accidentally or by mistake, a doctor should be consulted as soon as possible.
Protect from light. It should be stored in dry and cool places (below 25°C) with the lid tightly closed. Shelf life is 2 years from the date of manufacture.
Drug residues and empty drug containers should be buried in deep pits and should not be used for other purposes. Since honey bees, fish and other aquatic organisms are extremely sensitive to Cypermethrin, medicated washing water, drug residues, and empty containers should not be thrown into streams, lakes, and ponds, and should not be applied to beehives and their surroundings.
Cypercel Pour-On Solution is presented in cardboard boxes, in white plastic bottles of 100 ml, 200 ml, 250 ml, 500 ml and unboxed in bottles of 1000 ml.
Sold in veterinary clinics and pharmacies with a veterinarian's prescription.
APPROVAL DATE OF THE PROSPECTUS: 24.11.2021
T.R. MINISTRY OF AGRICULTURE AND FORESTRY MARKETING PERMISSION DATE AND NO: 25.04.2012-025/0092
Pİ FARMA İLAÇ SAN. VE TİC. A.Ş.
Malıköy Başkent OSB Mah. 26. Cad. No: 34/A - Sincan - ANKARA - TÜRKİYE
Pİ FARMA İLAÇ SAN. VE TİC. A.Ş.
Malıköy Başkent OSB Mah. 26. Cad. No: 34/A - Sincan - ANKARA - TÜRKİYE